ABSTRACT
Objective: To observe the changes of visual evoked potential (VEP) in diabetic rats and the influence of nerve growth factor (NGF) and aminoguanidine (AG) on VEP. Methods: Diabetes was induced in adult male Wistar rats with streptozotocin (STZ). Rats were divided into normal control group (CON), diabetes model group (DM), NGF-treated group (D +N) and AG-treated group(D+A). VEP was measured during the 3rd month, 6th month, 9th month, and 12th month. Results: Compared with the CON group, all rest groups had longer latencies and lower amplitudes (P<0.01). During the 6th and 9th months, the latencies in group D+N and group D+A were significantly decreased (P<0.05) compared with DM group, and the amplitude was partially recoved during the 6th month. The changes during the 12th month were similar to those of the 9th month, except that the amplitude in D+A group was slightly higher than that in the DM group. Conclusion: NGF and AG can improve DM-induced elongation of VEP latency and decrease of VEP amplitude.
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of phacoemulsification with foldable posterior chamber intraocular lens(PC-IOL) implantation in the management of acute or chronic primary angle-closure glaucoma(APACG or CPACG) with cataract.</p><p><b>METHODS</b>Twenty-six cases(28 eyes) with simple cataract and 60 cases(70 eyes)of PACG with cataract, including 14 eyes of preclinical APACG, 29 eyes of paroxysmal APACG, 27 eyes of CPACG. Visual acuity distributed from hand movement to 0.8. Phacoemulsification and intraocular lens implantation were performed and patients were followed up for(8.5+/-4.5) months.</p><p><b>RESULT</b>In simple cataract group, postoperative IOP did not decrease(t=1.9201, P>0.05); in preclinical APACG group, postoperative IOP decreased (t=3.9910, P<0.01); in paroxysmal APACG group, postoperative IOP decreased (t=4.7441, P<0.01); in CPACG groups, postoperative IOP decreased (t=4.4976, P<0.01). In APACG and CPACG groups postoperative antiglaucoma medication reduced. In APACG and CPACG groups, angle of anterior chamber was widen. Preoperative central and peripheral ACD of APACG and CPACG were much less than those of postoperative. In 56 eyes of PACG, visual acuity was corrected in 48 eyes(85.7%) including 28 eyes(50%) with corrected visual acuity>0.5.</p><p><b>CONCLUSION</b>The phacoemulsification with foldable posterior chamber intraocular lens implantation is beneficial for PACG with cataract, and the curative efficacy of APACG is better than that of CPACG.</p>
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Cataract , Cataract Extraction , Glaucoma, Angle-Closure , General Surgery , Lens Implantation, Intraocular , Methods , Phacoemulsification , Treatment Outcome , Visual AcuityABSTRACT
Objective:To observe the changes of visual evoked potential(VEP)in diabetic rats and the influence of nerve growth factor(NGF)and aminoguanidine(AG)on VEP.Methods:Diabetes was induced in adult male Wistar rats with streptozotocin(STZ).Rats were divided into normal control group(CON),diabetes model group(DM).NGF-treated group(D +N)and AG-treated group(D+A).VEP was measured during the 3~(rd)month,6~(th)month,9~(th)month,and 12~(th)month.Results: Compared with the CON group,all rest groups had longer latencies and lower amplitudes(P